2-Hydroxy-5-methoxybenzaldehyde → N-(3-Amino-4-fluorophenyl)-6-methoxy-2-oxo-2H-chromene-3-sulfonamide

HRID 1099710Notes

Reaction equation

HRID 1099710 reaction equation
[CH3:1][O:2][C:3]1[CH:10]=[C:7]([CH:8]=O)[C:6]([OH:11])=[CH:5][CH:4]=1.[NH2:12][C:13]1[CH:14]=[C:15]([CH:24]=[CH:25][C:26]=1[F:27])[NH:16][S:17]([CH2:20][C:21](O)=[O:22])(=[O:19])=[O:18]>C(O)(=O)C>[NH2:12][C:13]1[CH:14]=[C:15]([NH:16][S:17]([C:20]2[C:21](=[O:22])[O:11][C:6]3[C:7]([CH:8]=2)=[CH:10][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)(=[O:19])=[O:18])[CH:24]=[CH:25][C:26]=1[F:27]

Participants

4

Reactant 2

HCID 956952-Hydroxy-5-methoxybenzaldehydeHCID 613575983-Amino-4-fluoroanilinosulfonyl acetic acid

Product 1

HCID 11646267N-(3-Amino-4-fluorophenyl)-6-methoxy-2-oxo-2H-chromene-3-sulfonamide

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 5-methoxysalicylaldehyde (1 mmol) and 3-amino-4-fluoroanilinosulfonyl acetic acid (1 mmol) in acetic acid (10 mL) was subjected to the General Procedure 1, Method A to yield the title compound; m.p. 255-260° C.

Sources & evidence

ORD record
ord-1e0fee17bfc84ce3804558148243c8d5
Source dataset
uspto-grants-2012_03
Patent number
US08143428B2

Reaction notes

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