5-Chloro-salicylaldehyde → 3-(4-methoxybenzylsulfonyl)-6-chloro-2H-chromen-2-one

HRID 1099721Notes

Reaction equation

HRID 1099721 reaction equation
[Cl:1][C:2]1[CH:9]=[C:6]([CH:7]=O)[C:5]([OH:10])=[CH:4][CH:3]=1.[CH3:11][O:12][C:13]1[CH:26]=[CH:25][C:16]([CH2:17][S:18]([CH2:21][C:22](O)=[O:23])(=[O:20])=[O:19])=[CH:15][CH:14]=1>C(O)(=O)C>[CH3:11][O:12][C:13]1[CH:14]=[CH:15][C:16]([CH2:17][S:18]([C:21]2[C:22](=[O:23])[O:10][C:5]3[C:6]([CH:7]=2)=[CH:9][C:2]([Cl:1])=[CH:3][CH:4]=3)(=[O:19])=[O:20])=[CH:25][CH:26]=1

Participants

4

Reactant 2

HCID 124815-Chloro-salicylaldehydeHCID 120974144-Methoxybenzyl-sulfonylacetic acid

Product 1

HCID 866155283-(4-methoxybenzylsulfonyl)-6-chloro-2H-chromen-2-oneYield 66%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 5-chlorosalicylaldehyde (1 mmol) and 2-(4-methoxybenzylsulfonyl)acetic acid (1 mmol) in acetic acid (10 mL) was subjected to the General Procedure 2, Method A to generate a 66% yield of the title compound; m.p. 224-226° C.

Sources & evidence

ORD record
ord-79bbbd212859462e9b3a434d6958b5e7
Source dataset
uspto-grants-2012_03
Patent number
US08143428B2

Reaction notes

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