HRID11003

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C=CCN(C(=O)OCc1ccccc1)c1cnc2n(c1=O)[C@@H](C(=O)N(C(=O)OC(C)(C)C)c1ccccc1)C[C@@]2(C)CC(=O)OC(C)(C)C

HCID69600731

未命名化合物

结构：C=CCN(C(=O)OCc1ccccc1)c1cnc2n(c1=O)[C@H](C(=O)O)C[C@@]2(C)N=[N+]=[N-]

HCID86590672

未命名化合物

PRODUCTS

生成物

结构：C=CCN(C(=O)OCc1ccccc1)c1cnc2n(c1=O)[C@@H](C(=O)O)C[C@@]2(C)CC(=O)OC(C)(C)C

HCID69600615

未命名化合物

收率 89%

PROCEDURE

实验过程

According to the procedure for the preparation of 18f, intermediate 38b (413.9 mg, 0.62 mmol) was deprotected to afford 273.9 mg (89%) of intermediate 38c. MS (ESI) 498.4 (M+H+), 496.2 (M−H+).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f48e92db5f75411fa21ca293595467aa
来源数据集: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07094783B2
来源说明: uspto-grants-2006_08

反应 SMILES

[CH2:1]([N:4]([C:22]([O:24][CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=[O:23])[C:5]1[C:10](=[O:11])[N:9]2[C@H:12]([C:19]([OH:21])=[O:20])[CH2:13][C@:14](N=[N+]=[N-])([CH3:15])[C:8]2=[N:7][CH:6]=1)[CH:2]=[CH2:3].[C:32]([O:36][C:37](=[O:80])[CH2:38][C@@]1(C)C2=NC=C(N(CC=C)C(OCC3C=CC=CC=3)=O)C(=O)N2[C@@H](C(N(C(OC(C)(C)C)=O)C2C=CC=CC=2)=O)C1)([CH3:35])([CH3:34])[CH3:33]>>[CH2:1]([N:4]([C:22]([O:24][CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=[O:23])[C:5]1[C:10](=[O:11])[N:9]2[C@@H:12]([C:19]([OH:21])=[O:20])[CH2:13][C@:14]([CH2:38][C:37]([O:36][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:80])([CH3:15])[C:8]2=[N:7][CH:6]=1)[CH:2]=[CH2:3]