Potassium Carbonate → HCID 20555481, compound

Participants

Reaction Steps

A mixture of 4-[(7-chloro-1,2,4-benzotriazin-3-yl)thio]phenol (1.83 g), ethyl 2-bromopropionate (1.37 g), anhydrous potassium carbonate (0.96 g) and methyl ethyl ketone (50 ml) was heated under reflux for a period of 3 hours. The solvent was removed by distillation under reduced pressure and the residue was partitioned between water and dichloromethane. The organic phase was separated, dried (over anhydrous magnesium sulfate) and the solvent was removed by distillation under reduced pressure to give a solid. The crude product was purified by chromatography over silica gel (eluent dichloromethane) to give the title compound (1.95 g) as a crystalline solid, mp 86°-88° C.

Provenance & Evidence