反应详情

The compound (1.1 g) of Example 2 was dissolved in 20 ml of benzene, and 2 ml of thionyl chloride was added dropwise at room temperature with stirring. Then, the mixture was refluxed with stirring. The reaction mixture was concentrated, and n-hexane was added to the concentrate to crystallize it. The resulting crystals were collected by filtration, washed with n-hexane an dried to afford 980 mg of the desired product.

1. temperatureThen, the mixture was refluxed
2. stirringwith stirring
3. concentrationThe reaction mixture was concentrated
4. additionn-hexane was added to the
5. concentrationconcentrate
6. customto crystallize it
7. filtrationThe resulting crystals were collected by filtration
8. washwashed with n-hexane
9. customan dried