反应详情

The compound (57.3 mg) obtained in Example 5 was dissolved in 10 ml of benzene, and with stirring at room temperature, 0.5 ml of thionyl chloride was added. The mixture was refluxed for 3 hours with stirring. The reaction mixture was concentrated, and 5 ml of n-hexane was added to the concentrate to crystallize it. The resulting crystals were collected by filtration, washed with n-hexane and dried to afford 34.8 mg of the desired product.

1. temperatureThe mixture was refluxed for 3 hours
2. stirringwith stirring
3. concentrationThe reaction mixture was concentrated
4. addition5 ml of n-hexane was added to the
5. concentrationconcentrate
6. customto crystallize it
7. filtrationThe resulting crystals were collected by filtration
8. washwashed with n-hexane
9. customdried