2,2',4'-Trichloroacetophenone → HCID 178443972, compound

HRID 1105571Notes

Reaction equation

HRID 1105571 reaction equation
[CH2:1]([NH:8][C:9](=[S:12])[NH:10][NH2:11])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[Cl:13][C:14]1[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:15]=1[C:16](=O)[CH2:17]Cl>>[ClH:13].[Cl:13][C:14]1[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:15]=1[C:16]1[CH2:17][S:12][C:9]([NH:8][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7])=[N:10][N:11]=1

Participants

3

Reactant 2

HCID 202502,2',4'-TrichloroacetophenoneHCID 12999905HCID 12999905, compound

Product 1

HCID 178443972HCID 178443972, compound

Procedure

3.78 g (0.02 mole) of 4-n-heptyl-thiosemicarbazide and 4.67 g (0.02 mole) of 2,4-dichlorophenacyl chloride are reacted analogously to Example 1. After recrystallization from methanol/methyl acetate, 5.2 g of 5-(2,4-dichlorophenyl)-N-heptyl-6H-1,3,4-thiadiazin-2-amine monohydrochloride are produced. m.p. 175°-177° C.

Workup

  1. customAfter recrystallization from methanol/methyl acetate, 5.2 g of 5-(2,4-dichlorophenyl)-N-heptyl-6H-1,3,4-thiadiazin-2-amine monohydrochloride
  2. customare produced

Sources & evidence

ORD record
ord-d7670bb80cb04fc98ae7d76fb0dd1d15
Source dataset
uspto-grants-1982_01
Patent number
US04309426

Reaction notes

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