HCID 178493728, compound → HCID 178512636, compound

HRID 1105597Notes

Reaction equation

HRID 1105597 reaction equation
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:15]2[C:18](=[O:19])[C:17](=[O:20])[C:16]=2OC)[N:9]=1)[C:2]([NH2:4])=[NH:3]>CO>[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:16]2[C:17](=[O:20])[C:18](=[O:19])[C:15]=2[NH:14][CH2:13][CH2:12][CH2:11][CH2:10][C:8]2[N:9]=[C:5]([NH:1][C:2]([NH2:4])=[NH:3])[S:6][CH:7]=2)[N:9]=1)[C:2]([NH2:4])=[NH:3]

Participants

3

Reactant 1

HCID 178493728HCID 178493728, compound

Product 1

HCID 178512636HCID 178512636, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 2-quanidino-4-(4-aminobutyl)thiazole (0.105 g) and 1-[4-(2-guanidinothiazol-4-yl)butylamino]-2-methoxycyclobutene-3,4-dione (0.16 g) in dry methanol (5 ml) was stirred for 18 hours at room temperature. The white solid was filtered off, washed with methanol and dried in vacuo to give 1,2-bis[4-(2-guanidinothiazol-4-yl)-butylamino]cyclobutene-3,4-dione, 0.16 g., m.p. 228°-229° C.

Workup

  1. filtrationThe white solid was filtered off
  2. washwashed with methanol
  3. customdried in vacuo

Sources & evidence

ORD record
ord-89623582075b406f8581d8759356b3cb
Source dataset
uspto-grants-1982_01
Patent number
US04309435

Reaction notes

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