N-Benzylformamide → Ethyl N-Benzylformimidate

HRID 1105607노트

반응식

HRID 1105607 반응식
[CH2:1]([NH:8][CH:9]=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.F[B-](F)(F)F.[CH2:16]([O+](CC)CC)[CH3:17]>C(Cl)Cl>[CH2:1]([N:8]=[CH:9][O:10][CH2:16][CH3:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 80654N-BenzylformamideHCID 2723982Triethyloxonium tetrafluoroborate

생성물 1

HCID 19022221Ethyl N-Benzylformimidate

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution of 690 mg (5.1 mmoles) of N-benzylformamide in 5 ml of methylene chloride is cooled in an ice-water bath and put under an argon blanket. The solution is stirred while 4.9 ml (4.9 mmoles) of 1 M triethyloxonium fluoroborate in methylene chloride is added dropwise. After a 45 minute reaction time, the mixture is concentrated to dryness under reduced pressure at room temperature, and the residue is dried under reduced pressure over P2O5. The nuclear magnetic resonance spectrum of the product in deuterochloroform is fully in accord with the product being a fluoroborate etherate complex of ethyl N-benzylformimidate.

후처리

  1. additionis added dropwise
  2. customAfter a 45 minute reaction time
  3. concentrationthe mixture is concentrated to dryness under reduced pressure at room temperature
  4. dry with materialthe residue is dried under reduced pressure over P2O5

출처 및 근거

ORD 기록
ord-9773a04456cf40b988672616dc714388
출처 데이터셋
uspto-grants-1982_01
특허 번호
US04309438

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