Acetic Acid → HCID 70416995, compound

Participants

Reaction Conditions

Reaction Steps

0.25 g. of 9,15-dihydroxy-15-methyl-11-tetrahydropyranyloxy-13-thia-5-prostenoic acid p-benzoylaminophenyl ester (obtainable by the reaction of 2-(2-hydroxy-2-methylheptylthio)-5-hydroxy-3-tetrahydropyranyloxy-acetaldehyde lactol with triphenylphosphoniopentanoic acid p-benzoylaminophenyl ester in the presence of 2 moles of NaH) is stirred for 5 hours at 45° C. in 7 ml. of a mixture of acetic acid, THF and water (3:1:1). The solvent is distilled off, and after chromatographic purification of the residue (silica gel/ethyl acetate), 9,11,15-trihydroxy-15-methyl-13-thia-5-prostenoic acid p-benzoylaminophenyl ester is obtained.

Provenance & Evidence