2-Chloropropionic acid → Propionic acid, 2-(4-(4-chlorobenzyl)phenoxy)-, (+-)-

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Reaction Steps

129.8 Parts of 2-chloropropionic acid, 194 parts of 50% sodium hydroxide solution and 80 parts of water are mixed as described in Example 1. The clear, viscous liquid so obtained is added portionwise to a solution of 218.5 parts of 4-(4'-chlorobenzyl)-phenol in 1,000 parts of xylene; the reaction temperature being maintained at 110°-115° C. by azeotropic distillation of water in a water trap. The addition being complete, stirring is continued for 15 minutes at 110° C. Work-up is as described in Example 2. 290.5 Parts of 2-[4'-(4"-chlorobenzyl)-phenoxy]-propionic acid are obtained. The content of pure final product is 99.8%, corresponding to a yield of 99.8% of theory. The residual content of 4-(4'-chlorobenzyl)--phenol is 0.1%.

Provenance & Evidence