Water → HCID 12822539, compound

Participants

Reaction Steps

The starting material is prepared as follows: The mixture of 21.8 g of tetramethylenesuccinic anhydride (prepared from the diacid by refluxing with acetic anhydride), 12.1 g of 4-aminopyridine and 300 ml of xylene is refluxed on a water separator for 9 hours. The hot solution is filtered, cooled to 5° and the residue recrystallized from ethanol, to yield the 2-(4-pyridyl)-2-azaspiro[4,4]nonan-1,3-dione melting at 100°-103°.

Provenance & Evidence