p-Toluenesulfonic acid → HCID 20524766, compound

Participants

Reaction Steps

To a solution of N-(2-oxopropyl)-2'-chloro-6'-methyl-methanesulphonanilide (5.7 g) in methanol (80 ml) was added 4-toluenesulphonic acid (0.2 g), followed by trimethyl orthoformate (6.65 ml). The mixture was stirred at room temperature for 24 hours, then allowed to stand for 6 days. The solution was poured into dilute sodium bicarbonate solution, and the precipitated solid was collected by filtration, washed with water, and dried to give an off-white coloured solid of melting point 84°. Yield 6.0 g.

Provenance & Evidence