Ethylene Glycol → HCID 20524789, compound

Participants

Reaction Steps

A mixture of N-(2-oxopropyl)-4'-chloromethanesulphonanilide (6.0 g), ethane-1,2-diol (10 ml), 4-toluenesulphonic acid (0.1 g) and toluene (75 ml) was stirred and boiled under reflux with water separation by means of a Dean and Stark receiver. After 3 hours the reaction mixture was cooled and poured into water (about 200 ml) containing a few drops of sodium hydroxide solution. The organic layer was separated, washed with water, dried (MgSO4) and evaporated to a brown oil, which gave fawn coloured crystals from a solution in toluene/80°-100° petrol. Yield 6.0 g (86%). Melting point 84°-85°.

Provenance & Evidence