反应详情

温度

90 °C

32.6 g of α-[4-(4-trifluoromethylphenoxy)phenoxy]propionic acid was dissolved in 30 ml of ethanol, and an aqueous solution of 4.0 g of sodium hydroxide in 40 ml of water was added. The mixture was maintained at 70° to 75° C. for 1 hour. Then, ethanol and water were removed from the reaction product at reduced pressure. The residue was heated at 90° C. for 4 hours to afford 34.1 g (yield: 98%) of the final product as a white solid.

1. temperatureThe mixture was maintained at 70° to 75° C. for 1 hour
2. customThen, ethanol and water were removed from the reaction product at reduced pressure