1-Propanol → HCID 20554734, compound

Participants

Reaction Steps

A mixture of ethyl 2-{4-[N-methyl-N-(7-chloro-1,2,4-benzotriazin-3-yl)amino]phenoxy}propionate (80 g, compound No. 21, Example 7), n-propanol (800 ml) and concentrated sulfuric acid (3 ml) was heated under reflux for a period of 6 hours. A small volume of water was added and the mixture was concentrated. Dichloromethane was added and the mixture was washed first with dilute aqueous potassium carbonate solution and then with water. The organic phase was dried (over anhydrous magnesium sulfate) and the solvent was removed by distillation under reduced pressure to give the title compound (80 g) as a red oil.

Provenance & Evidence