HuagongsheHuagongshe Chemistry Print Report · For research reference only
[4S]-1-[(Phenylmethoxy)carbonyl]-4-(1-piperidinyl)-L-proline, methyl ester → [4S]-4-(1-Piperidinyl)-L-proline, methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [4S]-1-[(Phenylmethoxy)carbonyl]-4-(1-piperidinyl)-L-proline, methyl ester | HCID 131712640 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | [4S]-4-(1-Piperidinyl)-L-proline, methyl ester | HCID 131712641 | — |
Reaction Steps
A solution of 10.0 g of [4S]-1-[(phenylmethoxy)-carbonyl]-4-(1-piperidinyl)-L-proline, methyl ester in 100 ml of methanol is treated with a suspension of 2 g of 5% palladium on charcoal in 10 ml of water and placed under 3 atmospheres of hydrogen. After an equivalent quantity of hydrogen is consumed, the suspension is filtered and the solvent evaporated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04310461 |
| Source dataset | uspto-grants-1982_01 |
| ORD ID | ord-797d18ec20bc47d685edf9ed7a2f9ae0 |
| Source note | uspto-grants-1982_01 |