反应详情

To a -78° to -100° solution of 1.0 mol of 3-methoxyisophthalic acid dimethyl ester in 1-10 l of toluene is slowly added 1.0 mol of diisobutylaluminum hydride as a 1 M solution in n-hexane. The reaction is stirred for 3 hours after the addition and then quenched by the addition of 10 mol of anhydrous methanol. The reaction is allowed to warm to room temperature and stirred until a filterable precipitate forms. The reaction is filtered and the filtrate evaporated to a residue. The residue is purified by crystallization, distillation or chromatography to yield 3-methoxyisophthalaldehydic acid methyl ester.

1. customTo a -78° to -100°
2. additionafter the addition
3. stirringstirred until a filterable precipitate forms
4. filtrationThe reaction is filtered
5. customthe filtrate evaporated to a residue
6. distillationThe residue is purified by crystallization, distillation or chromatography