HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl chloroformate → HCID 20497036, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl chloroformate | HCID 6586 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | HCID 20555100 | HCID 20555100 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 20497036 | HCID 20497036 | — |
Reaction Steps
Analogously to Example 4(f), 8.0 g of 2-aminomethyl-3-(3-tert.-butylamino-2-hydroxy-propoxy)-aniline are reacted first with 3.3 g of methyl chloroformate in a mixture of 28 ml of isopropanol and 28 ml of water and then with 3.2 g of sodium methylate in 30 ml of methanol. After working up, 5-(3-tert.-butylamino-2-hydroxy-propoxy)-3,4-dihydro-1H-quinazolin-2-one with a melting point of 204°-205° is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04310527 |
| Source dataset | uspto-grants-1982_01 |
| ORD ID | ord-6ee77b6e76d047978afb277f750477cc |
| Source note | uspto-grants-1982_01 |