Benzoyl chloride → HCID 13023186, compound

HRID 1105837Notes

Reaction equation

HRID 1105837 reaction equation
[C:1]([NH:5][C:6](=[S:23])[NH:7][C:8]1[CH:9]=[C:10]([CH:19]=[CH:20][C:21]=1[NH2:22])[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:12])([O:3][CH3:4])=[O:2].[C:24](Cl)(=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>C1(C)C=CC=CC=1>[C:1]([NH:5][C:6](=[S:23])[NH:7][C:8]1[CH:9]=[C:10]([CH:19]=[CH:20][C:21]=1[NH:22][C:24](=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:12])([O:3][CH3:4])=[O:2]

Participants

4

Reactant 2

HCID 7412Benzoyl chlorideHCID 30369724-Amino-3-(3'-methoxycarbonyl-2'-thioureido)benzophenone

Product 1

HCID 13023186HCID 13023186, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a suspension of 3-(3-carbomethoxythioureido)-4-aminobenzophenone (3.29 g.) in toluene (200 ml.) is added benzoyl chloride (1.4 g.). The mixture is refluxed for 18 hours, cooled to room temperature and the precipitate collected, washed with hexane and dried to afford 2.8 g. (65% yield) of 3-(3-carbomethoxythioureido)-4-benzamidobenzophenone as a gray solid, m.p. 191°-192° C., dec.

Workup

  1. temperatureThe mixture is refluxed for 18 hours
  2. customthe precipitate collected
  3. washwashed with hexane
  4. customdried
  5. customto afford 2.8 g

Sources & evidence

ORD record
ord-1aac0dfee42d4aa389293573138ab584
Source dataset
uspto-grants-1982_01
Patent number
US04310537

Reaction notes

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