p-Toluenesulfonic acid → 3-Hydroxypropyl 4-[15-(trifluoromethyl)pentadecylamino]benzoate

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Reaction Steps

A mixture of 2.25 g. of methyl 4-[15-(trifluoromethyl)pentadecylamino]benzoate, 280 mg. of 1,3-propanediol and 1.37 g. of p-toluenesulfonic acid is heated at 180° C. for 18 hours and then is partitioned between ether and 3% aqueous sodium carbonate solution. The ether layer is separated, dried, and evaporated to yield the product as a white solid.

Provenance & Evidence