3-(3-Fluoro-4-methoxyphenyl)prop-2-enoic acid → 3-(3-Fluoro-4-methoxyphenyl)propionic acid

HRID 1105943Notes

Reaction equation

HRID 1105943 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][C:12]=1[O:13][CH3:14])[CH:5]=[CH:6][C:7]([OH:9])=[O:8]>C(O)C.[Pt]=O>[F:1][C:2]1[CH:3]=[C:4]([CH2:5][CH2:6][C:7]([OH:9])=[O:8])[CH:10]=[CH:11][C:12]=1[O:13][CH3:14]

Participants

4

Reactant 1

HCID 1018433-(3-Fluoro-4-methoxyphenyl)prop-2-enoic acid

Product 1

HCID 30179663-(3-Fluoro-4-methoxyphenyl)propionic acid

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent

Procedure

2.0 g of 3-fluoro-4-methoxy cinnamic acid was dissolved in 100 ml ethyl alcohol. To this was added 100 mg of platinum oxide as a catalyst. The mixture was hydrogenated in a Parr apparatus for 90 minutes. After the hydrogenation was over, the mixture was filtered and concentrated. The solid was crystallized by adding water. Yield=1.63 g. m.p. 107°-112° C.

Workup

  1. filtrationwas filtered
  2. concentrationconcentrated
  3. customThe solid was crystallized
  4. additionby adding water

Sources & evidence

ORD record
ord-2aa57f06b01e4086a0c05fce77302ad0
Source dataset
uspto-grants-1982_01
Patent number
US04310675

Reaction notes

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