Ethyl bromoacetate → HCID 53885943, compound

HRID 1105963Notes

Reaction equation

Br[CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4].[CH2:8]([C:10]1([CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH2:19][C:18]2[C:13](=[C:14]([O:22]CC3C=CC=CC=3)[CH:15]=[C:16]([CH:20]=O)[CH:17]=2)[C:12](=[O:30])[CH2:11]1)[CH3:9]>>[CH2:8]([C:10]1([CH2:31][C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=2)[CH2:19][C:18]2[C:13](=[C:14]([OH:22])[CH:15]=[C:16]([CH2:20][CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4])[CH:17]=2)[C:12](=[O:30])[CH2:11]1)[CH3:9]

Participants

Reactant 2

HCID 7748Ethyl bromoacetate

HCID 20531466HCID 20531466, compound

Product 1

HCID 53885943HCID 53885943, compound

Procedure

Ethyl bromoacetate is converted to the triphenyl phosphorone, reacted with the product of Example 36 and reduced catalytically to the desired compound using procedures analogous to those described in Example 24.

Sources & evidence

ORD record: ord-8b4c56dc16f044818822b92241060b5a
Source dataset: uspto-grants-1982_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04310668

Reaction notes

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