HCID 12760710, compound → HCID 12760711, compound

Participants

Reaction Steps

To 640 ml. of 1.0 M. boranetetrahydrofuran complex in tetrahydrofuran is added a solution of 81 g. of 8-(2-furoyl)-2-hydroxyoctanoic acid in 240 ml. of tetrahydrofuran during one hour while maintaining a temperature of 0°-10° C. After the addition, the solution is stirred at room temperature for 3 hours, is cooled to 0° C., and treated cautiously with 80 ml. of 1:1 aqueous tetrahydrofuran. The resulting mixture is diluted with ethyl acetate. The solution is washed successively with an ice-cold brine-hydrochloric acid mixture, brine, brinesodium bicarbondate solution and brine. The solution is dried over magnesium sulfate and concentrated to give an oil; pmr (CDCl3) δ 4.70 (triplet).

Provenance & Evidence