Dimethyl Sulfoxide → HCID 20554019, compound

Participants

Reaction Steps

20.7 g of potassium carbonate, 19.2 g (0.05 mole) of 3-(2'-chloro-4'-trifluoromethylphenoxy)-6-chlorophenoxy-chloroethane and 5.3 g (0.05 mole) of methyl thioglycolate are added at room temperature to 80 ml of dimethyl sulfoxide. In the course of the exothermic reaction, the temperature rises to about 42° C. The reaction mixture is then stirred overnight at room temperature. On the next day, the batch is diluted with 300 ml of ether and the ethereal solution is washed with two 400 ml portions of 20% K2CO3 solution. The organic phase is dried over magnesium sulfate and concentrated, affording 17.8 g of a light yellow oil with a refractive index of nD21 1.5487. The following compounds were obtained in analogous manner:

Provenance & Evidence