Pyrrolidine → HCID 20554376, compound

Participants

Reaction Steps

1.35 g (19 mmol) of pyrrolidine are added slowly at 40° C. to a solution of 3 g (7 mmol) of 11-chloroacetyl-6-methyl-2-phenyl-5,6-dihydropyrimido[4,5-b][1,5]benzodiazepin-5-one in 30 ml of absolute toluene, while stirring. The mixture is stirred for a further 6 hours at 60° C. After filtration the solvent is removed on a rotary evaporator, and the residue is purified by chromatography on neutral silica gel using 99:1 chloroform/methanol as the eluant. After removing the solvent, the residue is stirred with methanol and finally recrystallized from ethanol; yield 1.1 g (34%), m.p. 196° C.

Provenance & Evidence