Acetic Acid → HCID 15535477, compound

Participants

Reaction Steps

34.8 g (0.1 mol) of 5-ethoxycarbonyl-4-(2-methylaminoanilino)-2-phenylpyrimidine are added to a freshly prepared, hot solution of 6.8 g (0.296 mol) of sodium in 99 ml of absolute ethanol, while stirring. The orange-colored suspension which has been formed thereby is heated for a further 30 minutes under reflux and is allowed to cool; 19.7 ml of glacial acetic acid and 19.4 ml of water are added and the mixture is stirred for a further 30 minutes. The yellow precipitate is filtered off, washed with water and dried in vacuo; yield: 26 g, with m.p. 227° C. (from ethanol).

Provenance & Evidence