Ammonia → HCID 53833362, compound

HRID 1106065Notes

Reaction equation

C([S:4][CH2:5][CH:6]([C:21]([F:24])([F:23])[F:22])[C:7]([N:9]1[CH2:16][C:15]([O:19][CH3:20])([O:17][CH3:18])[CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8])(=O)C.N>>[SH:4][CH2:5][CH:6]([C:21]([F:24])([F:22])[F:23])[C:7]([N:9]1[CH2:16][C:15]([O:17][CH3:18])([O:19][CH3:20])[CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8]

Participants

Reactant 2

HCID 222Ammonia

HCID 54227772HCID 54227772, compound

Product 1

HCID 53833362HCID 53833362, compound

Procedure

Each individual isomer product from Example 19 is hydrolyzed with concentrated ammonia according to the procedure of Example 4 to yield 1-(3-mercapto-2-trifluoromethyl-1-oxopropyl)-4,4-dimethoxy-L-proline, isomer A and 1-(3-mercapto-2-trifluoromethyl-1-oxopropyl)-4,4-dimethoxy-L-proline, isomer B.

Sources & evidence

ORD record: ord-1d9ad7e3fd404307b00c1eabc42d928d
Source dataset: uspto-grants-1982_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04311697

Reaction notes

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