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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1106069Generated: October 31, 2026

L-Proline, 4,4-dimethoxy- → 1-[3-(acetylthio)-2-methylthio-1-oxopropyl]-4,4-dimethoxy-L-proline

https://huagongshe.com/reaction/1106069

Reaction equation

Participants

RoleNameHCIDCharge
ReactantL-Proline, 4,4-dimethoxy-HCID 12821175—
Reactant3-(Acetylthio)-2-(methylthio)propionic acid chlorideHCID 54341183—
Reactant(8S)-7-(3-mercapto-2-methylthio-1-oxopropyl)-1,4-dioxo-7-azaspiro[4.4]nonane-8-carboxylic acidHCID 57148383—
Product1-[3-(acetylthio)-2-methylthio-1-oxopropyl]-4,4-dimethoxy-L-prolineHCID 53683698—

Reaction Steps

4,4-Dimethoxy-L-proline is reacted with 3-(acetylthio)-2-(methylthio)propionic acid chloride according to the procedure of Example 3 (d) to yield 1-[3-(acetylthio)-2-methylthio-1-oxopropyl]-4,4-dimethoxy-L-proline.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04311697
Source datasetuspto-grants-1982_01
ORD IDord-a7844361359140ffaad2ce18313fb17d
Source noteuspto-grants-1982_01