Ammonia → 1-(3-mercapto-2,2-dimethyl-1-oxopropyl)-4,4-dimethoxy-L-proline

HRID 1106080Notes

Reaction equation

C([S:4][CH2:5][C:6]([CH3:22])([CH3:21])[C:7]([N:9]1[CH2:16][C:15]([O:19][CH3:20])([O:17][CH3:18])[CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8])(=O)C.N>>[SH:4][CH2:5][C:6]([CH3:22])([CH3:21])[C:7]([N:9]1[CH2:16][C:15]([O:19][CH3:20])([O:17][CH3:18])[CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8]

Participants

Reactant 2

HCID 222Ammonia

HCID 540385561-[3-(acetylthio)-2,2-dimethyl-1-oxopropyl]-4,4-dimethoxy-L-proline

Product 1

HCID 539083161-(3-mercapto-2,2-dimethyl-1-oxopropyl)-4,4-dimethoxy-L-proline

Procedure

The product from part (a) is hydrolyzed with concentrated ammonia according to the procedure of Example 4 to give 1-(3-mercapto-2,2-dimethyl-1-oxopropyl)-4,4-dimethoxy-L-proline.

Sources & evidence

ORD record: ord-4f387f6cd5674af7aec85c6712c29614
Source dataset: uspto-grants-1982_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04311697

Reaction notes

Loading…