Ammonia → HCID 131712646, compound

HRID 1106089Notes

Reaction equation

C([S:4][CH2:5][CH:6]([CH3:22])[C:7]([N:9]1[CH2:17][C:16]([O:20][CH3:21])([O:18][CH3:19])[CH2:15][C@H:10]1[C:11]([O:13][CH3:14])=[O:12])=[O:8])(=O)C.N>>[SH:4][CH2:5][CH:6]([CH3:22])[C:7]([N:9]1[CH2:17][C:16]([O:20][CH3:21])([O:18][CH3:19])[CH2:15][C@H:10]1[C:11]([O:13][CH3:14])=[O:12])=[O:8]

Participants

Reactant 2

HCID 222Ammonia

HCID 14036305HCID 14036305, compound

Product 1

HCID 131712646HCID 131712646, compound

Procedure

The product from Example 130 is hydrolyzed with concentrated ammonia according to the procedure of Example 4 to yield (S)-1-(3-mercapto-2-methyl-1-oxopropyl)-4,4-dimethoxy-L-proline, methyl ester.

Sources & evidence

ORD record: ord-9d30a0b501174410914681a5162d97d2
Source dataset: uspto-grants-1982_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04311697

Reaction notes

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