Propionic Acid → HCID 70546288, compound

HRID 1106091Notes

Reaction equation

HRID 1106091 reaction equation
[NH2:1][CH2:2][CH:3]([OH:29])[CH2:4][NH:5][CH:6]([CH2:18][CH2:19][C:20]1[CH:25]=[CH:24][C:23]([CH:26]([CH3:28])[CH3:27])=[CH:22][CH:21]=1)[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]([CH3:17])[CH3:16])=[CH:11][CH:10]=1.[C:30]([OH:34])(=[O:33])[CH2:31][CH3:32]>CCOCC>[C:30]([OH:34])(=[O:33])[CH2:31][CH3:32].[C:30]([OH:34])(=[O:33])[CH2:31][CH3:32].[NH2:1][CH2:2][CH:3]([OH:29])[CH2:4][NH:5][CH:6]([CH2:18][CH2:19][C:20]1[CH:21]=[CH:22][C:23]([CH:26]([CH3:28])[CH3:27])=[CH:24][CH:25]=1)[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]([CH3:17])[CH3:16])=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 1032Propionic AcidHCID 12797297HCID 12797297, compound

Product 1

HCID 70546288HCID 70546288, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a stirred solution of 1-amino-3-{{3-[4-(1-methylethyl)phenyl]-1-{2-[4-(1-methylethyl)phenyl]ethyl}propyl}amino]-2-propanol (3.97 g., 0.01 m.) in anhydrous ether (ca. 50 ml.) is added dropwise over ca. 10 minutes a mixture of propionic acid (1.49 g., 0.02 m.) and ether (10 ml.). The resultant mixture is allowed to stir at ambient temperature for several hours, and the ether then removed in vacuo to yield 1-amino-3-{{3-[4-(1-methylethyl)-phenyl]-1-{2-[4-(1-methylethyl)phenyl]ethyl}propyl}amino]-2-propanol dipropionate.

Workup

  1. customthe ether then removed in vacuo

Sources & evidence

ORD record
ord-c7db4af150cf4863b4fb07e2184f11a7
Source dataset
uspto-grants-1982_01
Patent number
US04311709

Reaction notes

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