Dimethylformamide → HCID 178475077, compound

Participants

Reaction Steps

A solution of 11.3 g (32.8 mmol) of the above pyrimidine acid and 160 ml of dimethylformamide is stirred at room temperature and 16.0 g (98.4 mmol) of carbonyldiimidazole is added. After 4 hrs at room temperature the dimethylformamide is evaporated under high vacuum at 45° C. to give an oily residue. Acetonitrile (300 ml) is added and solution is obtained by heating on a steam bath and a solid separates almost immediately. The mixture is cooled and the solid filtered, washed with acetonitrile, and dried to give 9.2 g of the title imidazolide.

Provenance & Evidence