Dimethylformamide → HCID 178475082, compound

Participants

Reaction Steps

A mixture of 3.72 g (10 mmol) of the above pyrimidine acid, 3.24 g (20 mmol) of carbonyldiimidazole, and 25 ml of dimethylformamide is stirred at 49°-52° C. for 30 min. The solution is treated with 50 ml of tetrahydrofuran and 200 ml of ether and stored in the cold overnight. The solid is filtered, washed with ether and dried to give 2.63 g of the title imidazolide.

Provenance & Evidence