HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzocaine → Ethyl 4-(11-hydroxyundecylamino)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzocaine | HCID 2337 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Hexamethylphosphoramide | HCID 12679 | — |
| Reactant | 11-Bromo-1-undecanol | HCID 74163 | — |
| Solvent | Water | HCID 962 | — |
| Product | Ethyl 4-(11-hydroxyundecylamino)benzoate | HCID 20482494 | — |
Reaction Steps
A solution of 16 g. of 11-bromoundecanol, 9.9 g. of ethyl 4-aminobenzoate, and 6.0 g. of triethylamine in 50 ml. of hexamethylphosphoramide is stirred at 70° C. under argon for 128 hours. The resulting solution is cooled, diluted with water, and filtered. Recrystallization of the solid from acetonitrile affords ethyl 4-(11-hydroxyundecylamino)benzoate as a white, crystalline solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04311846 |
| Source dataset | uspto-grants-1982_01 |
| ORD ID | ord-f2b1b7c21714454a9b801cb9dbc0ce85 |
| Source note | uspto-grants-1982_01 |