Ethanol → HCID 73679600, compound

HRID 1106178Notes

Reaction equation

HRID 1106178 reaction equation
[N:1](=[C:3]([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][NH:9][C:10]1[CH:20]=[CH:19][C:13]([C:14]([O:16]CC)=[O:15])=[CH:12][CH:11]=1)[OH:2].[OH-].[K+].C(O)C>O>[N:1](=[C:3]([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][NH:9][C:10]1[CH:11]=[CH:12][C:13]([C:14]([OH:16])=[O:15])=[CH:19][CH:20]=1)[OH:2]

Participants

5

Reactant 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 86737438HCID 86737438, compound

Product 1

HCID 73679600HCID 73679600, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of the ethyl 4-(6-oximinohexadecylamino)benzoate, 1.0 g. of potassium hydroxide and 15 ml. of ethanol in 15 ml. of water is stirred under reflux for 2 hours, evaporated, and then treated with 15 ml. of water and 2.3 ml. of concentrated hydrochloric acid. The mixture is extracted with methylene chloride and the dried extract is evaporated. Crystallization from ethanol-water affords the product as a white solid.

Workup

  1. temperatureunder reflux for 2 hours
  2. customevaporated
  3. additiontreated with 15 ml
  4. extractionThe mixture is extracted with methylene chloride
  5. extractionthe dried extract
  6. customis evaporated
  7. customCrystallization from ethanol-water

Sources & evidence

ORD record
ord-3255a7f357de422d819539f9ff57e239
Source dataset
uspto-grants-1982_01
Patent number
US04311846

Reaction notes

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