Phenolphthalein → HCID 13023279, compound

Participants

Reaction Steps

To a stirred solution containing 16.9 g (0.10 mol) of disodium-N-phosphonomethylglycine in water at 20°-25° C. was added 15 g (0.11 mol) of n-butyl chloroformate. After stirring the reaction mixture for 2 hours, a 50% sodium hydroxide solution was slowly added until the pH of the mixture stabilized at a phenolphthalein endpoint. The reaction mixture was concentrated and the residue dried over potassium hydroxide pellets to yield 42.3 g of N-n-butoxycarbonyl-N-phosphonomethylglycine, disodium salt, as a white solid having the following analysis: Calculated: C, 33.00; H, 5.19; P, 10.64. Found: C, 32.77; H, 5.16; P, 10.69.

Provenance & Evidence