Methyl iodide → HCID 12909447, compound

Participants

Reaction Steps

The mixture of 5.0 g of 2-(p-chlorophenyl)-pyrazolo[4,3-c]quinolin-3(5H)-one, 0.81 g of 50% sodium hydride in mineral oil and 100 ml of anhydrous tetrahydrofuran is refluxed for 2 hours. It is cooled to room temperature, combined with 3.0 g of methyl iodide while stirring and another 1.0 g thereof is added after one hour. The mixture is stirred overnight at room temperature, filtered and the residue recrystallized from tetrahydrofuran-heptane, to yield the 5-methyl-2-(p-chlorophenyl)-pyrazolo[4,3-c]quinolin-3-one melting at 322°-323°.

Provenance & Evidence