Sodium hydride → HCID 13093688, compound

Participants

Reaction Steps

The mixture of 10.0 g of 2-(p-chlorophenyl)-pyrazolo-[4,3-c]quinolin-3(5H)-one, 1.8 g of 50% sodium hydride in mineral oil and 250 ml of 1,2-dimethoxyethane is stirred at 100° until dissolution. It is cooled to room temperature and 15.0 g of 3-dimethylaminopropyl chloride in 10 ml of 1,2-dimethoxyethane are added. The mixture is stirred at 150° overnight, cooled, the supernatant solution decanted off and the residue treated with said solvent, to yield the 5-(3-dimethylaminopropyl)-2-(p-chlorophenyl)-pyrazolo-[4-3-c]quinolin-3-one melting at 189°-191°. Similarly the 5-(2-dimethylaminoethyl)-analog is obtained, m.p. 184°-186°.

Provenance & Evidence