Formaldehyde → HCID 178482194, compound

Participants

Reaction Steps

To the mixture of 1.4 g of 2-(p-aminophenyl)-pyrazolo-[4,3-c]quinolin-3(5H)-one, 4.1 ml of 37% aqueous formaldehyde, 1.0 g of sodium cyanoborohydride and 20 ml of acetonitrile, 0.6 g of glacial acetic acid are added while stirring. Stirring is continued overnight at room temperature and the mixture diluted with water. The precipitate formed is dissolved in diluted sodium hydroxide, the aqueous solution washed with diethyl ether and its pH adjusted to 8.5 by addition of aqueous ammonium chloride. The precipitate formed is collected, washed with methanol, then with diethyl ether and dried to yield the 2-(p-methylaminophenyl)-pyrazolo[4,3-c]quinolin-3(5H)-one melting at 302°-304°.

Provenance & Evidence