1,1,2,2-Tetrachloroethane → HCID 12909448, compound

Participants

Reaction Steps

The mixture of 650 mg of 1-(p-chlorophenyl)-2-methyl-4-anilinomethylidene-pyrazolidin-3,5-dione, 2.0 g of ethyl polyphosphate and 10 ml of 1,1,2,2-tetrachloroethane is refluxed for 24 hours. The solution is poured onto 10 ml of 2 N aqueous sodium hydroxide and the organic layer chromatographed on silica gel plates, using toluene:ethanol:conc. ammonium hydroxide (80:20:1) as eluent, to yield the 2-(p-chlorophenyl)-1-methyl-pyrazolo[4,3-c] quinolin-3-one with an Rf=0.48. When using dichloromethane:methanol (19:1) as eluent, said compound has the Rf=0.33; it is identical with that of Example 4.

Provenance & Evidence