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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1106276Generated: October 26, 2026

3-(Trifluoromethyl)benzyl chloride → 1-(3-Trifluoromethylbenzyl)-4-(2-hydroxy-3-n-hexadecyloxypropyl)piperazine

https://huagongshe.com/reaction/1106276

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Trifluoromethyl)benzyl chlorideHCID 69716—
Reactant1-(2-Hydroxy-3-n-hexadecyloxypropyl)-piperazineHCID 13037790—
Product1-(3-Trifluoromethylbenzyl)-4-(2-hydroxy-3-n-hexadecyloxypropyl)piperazineHCID 13037796—

Reaction Steps

Following the procedure of Example 5, 1-(2-hydroxy-3-n-hexadecyloxypropyl)-piperazine was reacted with 3-(trifluoromethyl)benzyl chloride to form 1-(3-trifluoromethylbenzyl)-4-(2-hydroxy-3-n-hexadecyloxypropyl)-piperazine, mp 133°-135° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04312877
Source datasetuspto-grants-1982_01
ORD IDord-990595243b6646549163f3b385bc5c9f
Source noteuspto-grants-1982_01