HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → 4-Cyano-1-(2-hydroxy-3-n-hexadecyloxypropyl)-4-phenylpiperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 4-Piperidinecarbonitrile, 4-phenyl- | HCID 181138 | — |
| Reactant | 2,3-Epoxypropyl-n-hexadecylether | HCID 18000085 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-Cyano-1-(2-hydroxy-3-n-hexadecyloxypropyl)-4-phenylpiperidine | HCID 13037802 | 62% |
Reaction Conditions
| Temperature | 185 °C |
|---|
Reaction Steps
4-Cyano-4-phenylpiperidine (1.1 g, 0.0059 mol) and 2,3-epoxypropyl-n-hexadecylether (1.6 g, 0.0056 mol) were combined and heated to 185° C. for 30 minutes. After cooling, ethyl acetate (20 ml) and acetonitrile (20 ml) were added, and the resulting solid was collected by filtration (1.6 g, 62% yield): mp 69°-70° C.; ir (KBr) 2227 cm-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04312877 |
| Source dataset | uspto-grants-1982_01 |
| ORD ID | ord-6fb00ffb2868420ea2f0537e4bffd664 |
| Source note | uspto-grants-1982_01 |