HCID 12851065, compound → HCID 13019104, compound

HRID 1106281Notes

Reaction equation

HRID 1106281 reaction equation
CN[C@@H]1[C@@H](O)[C@H](O[C@H]2O[C@H](CN)CC[C@H]2N)[C@@H](N)C[C@H]1O.C[NH:23][CH2:24][C@H:25]1[O:30][C@H:29]([O:31][C@H:32]2[C@H:37]([OH:38])[C@H:36]([NH:39][CH3:40])[C@H:35]([O:41][CH3:42])[CH2:34][C@@H:33]2[NH2:43])[C@H:28]([NH2:44])[CH2:27][CH2:26]1.CNC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@H](NC)[C@@H](OC)C[C@@H]2N)[C@H](N)CC1>>[CH3:40][NH:39][C@@H:36]1[C@@H:37]([OH:38])[C@H:32]([O:31][C@H:29]2[O:30][C@H:25]([CH2:24][NH2:23])[CH2:26][CH2:27][C@H:28]2[NH2:44])[C@@H:33]([NH2:43])[CH2:34][C@H:35]1[O:41][CH3:42]

Participants

4

Reactant 3

HCID 12851065HCID 12851065, compoundHCID 13019099HCID 13019099, compoundHCID 13019100HCID 13019100, compound

Product 1

HCID 13019104HCID 13019104, compound

Procedure

Active fractions Nos. 96 to 112 were lyophilized to afford 0.65 g of a crude powder containing substance KA-7038. Lyophilization of active fractions Nos. 113 to 134 afforded 0.4 g of a crude powder of substance KA-7038 I and substance KA-7038 VII. Lyophilization of fractions Nos. 135 to 149 afforded 0.36 g of a crude powder of a mixture of substance KA-7038 I, substance KA-7038 II and substance KA-7038 VI. Furthermore, 0.9 g of a free base of substance KA-7038 III was obtained from fractions Nos. 150 to 172.

Workup

  1. custom135 to 149 afforded

Sources & evidence

ORD record
ord-be8bfd7d50fc40c29a6ffd408142e02d
Source dataset
uspto-grants-1982_01
Patent number
US04312858

Reaction notes

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