Triethylamine → HCID 18787876, compound

Temperature

-15 °C

3-Phtalimido-propanoic acid (IV.1) (0.74 g, 3.375 mmol) was dissolved in tetrahydrofuran (15 ml, dried over potassium and distilled) under nitrogen, Triethylamine (0.494 ml, 3.54 mmol, 5% excess) was added to this solution and the mixture was cooled to -15° C. iso-Butyl chloroformate (0.46 ml, 3.54 mmol in 5 ml dry tetrahydrofuran) was added dropwise while maintaining the temperature at -15° C. After 15 minutes, N-benzyloxy-2-phtalimidoethylamine (IV.5) (1 g, 3.375 mmol in 10 ml dry tetrahydrofuran) was added dropwise at -15° C. and under nitrogen. The mixture was stirred during 3 hours at -15° C. and at room temperature overnight. The solvent was evaporated under reduced pressure and the residue was taken up in ethyl acetate (25 ml). The solution was extracted with water (25 ml), saturated sodium carbonate (25 ml), water (25 ml), 1M hydrochloric acid (25 ml), water (25 ml) and brine (25 ml). The organic solution was dried over magnesium sulfate, filtered and evaporated. The remaining white residue was recrystallized in hexane/ethyl acetate. The title compound was isolated as white crystals that were dried under vacuum. Yield: 53%

1. additionwas added dropwise
2. customThe solvent was evaporated under reduced pressure
3. extractionThe solution was extracted with water (25 ml), saturated sodium carbonate (25 ml), water (25 ml), 1M hydrochloric acid (25 ml), water (25 ml) and brine (25 ml)
4. dry with materialThe organic solution was dried over magnesium sulfate
5. filtrationfiltered
6. customevaporated
7. customThe remaining white residue was recrystallized in hexane/ethyl acetate

ORD record

ord-dab030f373364a39a192640239df6566

Source dataset

uspto-grants-2000_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06056939