8-(3-Fluorophenyl)-1,4-dioxaspiro[4.5]dec-7-ene → 8-(3-Fluorophenyl)-1,4-dioxaspiro[4.5]decane

Participants

Reaction Steps

306.3 g of 8-(3-fluorophenyl)-1,4-dioxaspiro[4.5]dec-7-ene were dissolved in 3 l of THF, and 30 g of 5% Pd/C were added. The mixture was then hydrogenated at atmospheric pressure. The resultant solution was filtered and evaporated to a residue. The residue was recrystallized twice from 200 ml of hexane at -60° C., giving 8-(3-fluorophenyl)-1,4-dioxaspiro[4.5]decane.

Provenance & Evidence