反应详情

温度

25 °C

128.0 g of 8-(3-fluoro-4-iodophenyl)-1,4-dioxaspiro-[4.5]decane and 320 ml of formic acid were dissolved in 750 ml of toluene and stirred at 25° C. overnight, the HCOOH phase was run off, diluted with 2 1 of water and extracted twice with toluene, and the toluene phases were washed with water and sodium hydrogencarbonate solution until neutral, dried and evaporated. The crude product was recrystallized at -25° C. from 100 ml of hexane containing a few drops of ethyl acetate, giving 4-(3-fluoro-4-iodophenyl)cyclohexanone.

1. extractionextracted twice with toluene
2. washthe toluene phases were washed with water and sodium hydrogencarbonate solution until neutral,
3. customdried
4. customevaporated
5. customThe crude product was recrystallized at -25° C. from 100 ml of hexane containing a few drops of ethyl acetate