Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 18788044 | HCID 18788044 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 18788043 | HCID 18788043 | — |
Reaction Steps
A mixture of 2,2-dimethyl N-isobutylindoline (2.0 g) and concentrated hydrochloric acid (4.5 cm3) was cooled to 8° C. and sodium nitrite (0.8 g) in water (2 cm3) was added dropwise. The reaction mixture was allowed to warm to ambient temperature, made alkaline with sodium hydroxide solution an extracted with ethyl acetate. The ethyl acetate was dried over magnesium sulphate, filtered and evaporated to give 5-nitroso-2,2-dimethyl N-isobutyl indoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06057264 |
|---|
| Source dataset | uspto-grants-2000_05 |
|---|
| ORD ID | ord-a69fbc905308480390eac4f940ab84a9 |
|---|
| Source note | uspto-grants-2000_05 |
|---|
