Sodium Carbonate → HCID 18788040, compound

Participants

Reaction Conditions

Reaction Steps

To 2,2-dimethyl-N-n-heptylindoline (12.5 g) in dimethylformamide (100 cm3) phosphorus oxychloride (15.3 g) was added at 5° C. before heating the mixture at 80° C. for 2-5 hours. The reaction mixture was cooled, poured onto ice, neutralised with solid sodium carbonate and extracted into toluene. The toluene was washed with water, separated, dried over magnesium sulphate, filtered and evaporated to leave an oil. The oil was eluted from silica using dichloromethane as eluent, evaporation of the solvent gave 2,2-dimethyl-5-formyl-N-n-heptylindoline (4.9 g, 36.1%).

Provenance & Evidence