HCID 21253057, compound → HCID 21253077, compound

HRID 1106435Notes

Reaction equation

HRID 1106435 reaction equation
[Br:1][C:2]1[C:11]2[CH2:10][N:9]([CH2:12][C:13]3[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=3)[CH2:8][CH2:7][C:6]=2[C:5]([NH2:23])=[C:4]([N+:24]([O-])=O)[CH:3]=1>CO.[Pd]>[BrH:1].[F:21][C:19]([F:20])([F:22])[C:16]1[CH:15]=[CH:14][C:13]([CH2:12][N:9]2[CH2:8][CH2:7][C:6]3[C:11](=[CH:2][CH:3]=[C:4]([NH2:24])[C:5]=3[NH2:23])[CH2:10]2)=[CH:18][CH:17]=1

Participants

4

Reactant 1

HCID 21253057HCID 21253057, compound

Product 1

HCID 21253077HCID 21253077, compoundYield 88.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of product from Example 24 (0.91 g, 2.1 mmol) in methanol (100 mL was shaken over 20% Pd/C under hydrogen and pressure for 15 minutes. The catalyst was filtered off and concentrated under vacuum to give the title compound (0.75 g, 88% yield) as a red-brown solid, mp=131-136° C.

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-ff9903905b2441d1b868d3b7e9d0ceed
Source dataset
uspto-grants-2000_05
Patent number
US06057313

Reaction notes

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